ADP-ribosyl cyclase 1



ADP-ribosyl cyclase 1 (ADPRC1) in human and mouse is also named Cluster of Differentiation 38 (CD38). It catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca++ signaling. The images at the left and at the right correspond to one representative ADPRC1, i.e. the crystal structure of human ADP-ribosyl cyclase 1 (2ef1).

3D Structures of human ADP-ribosyl cyclase 1
Update June 2011

ADPRC1
2eg9 - CD38 enzymatic domain (mutant) – mouse

2ef1 - hCD38 enzymatic domain – human

1yh3 - hCD38 enzymatic domain (mutant)

1zvm - hCD38 (mutant)

ADPRC1 binary complex
3i9m, 3i9n – hCD38 enzymatic domain+ADPR analog 3f6y – hCD38 enzymatic domain+Ca++

3dzf - hCD38 enzymatic domain+intermediate

3dzg - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex

3dzh - hCD38 enzymatic domain (mutant)+GTP

3dzi - hCD38 enzymatic domain (mutant)+intermediate/GTP complex

3dzj, 3dzk - hCD38 enzymatic domain (mutant)+NMN complex

2pgj, 2pgl - hCD38 enzymatic domain (mutant)+substrate analog

2o3t - hCD38 enzymatic domain (mutant)+cGDPR

2o3u - hCD38 enzymatic domain (mutant)+NGD

2o3q, 2o3r, 2o3s - hCD38 enzymatic domain (mutant)+cADPR

2i65 – hCD38+NAD

2i66 - hCD38 (mutant)+GDP intermediate

2i67 - hCD38 (mutant)+ADPR

2hct - hCD38 enzymatic domain (mutant)+NMN

3ofs - hADPRC1 enzymatic domain (mutant) + inhibitor

3raj - hADPRC1 enzymatic domain (mutant) + antibody